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KMID : 0043320150380101774
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Archives of Pharmacal Research
2015 Volume.38 No. 10 p.1774 ~ p.1782
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Two new naphthalene glucosides and other bioactive compounds from the carnivorous plant Nepenthes mirabilis
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Thanh Nguyen Van
Thao Nguyen Phuong
Dat Le Duc
Huong Phan Thi Thanh
Lee Sang-Hyun
Jang Hae-Dong
Cuong Nguyen Xuan
Nam Nguyen Hoai
Kiem Phan Van
Minh Chau Van
Kim Young-Ho
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Abstract
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Two new naphthalene diglucosides named nepenthosides A (1) and B (2), together with eleven known compounds (3?13), were isolated from the carnivorous plant Nepenthes mirabilis. The structures of these compounds were elucidated based on extensive spectroscopic analysis, including 1D- and 2D-NMR, and MS. The antioxidant activities of compounds 1?13 were evaluated in terms of their peroxyl radical-scavenging (trolox equivalent, TE) and reducing capacities. All isolates showed peroxyl radical-scavenging and reducing activities at concentrations of 1.0 and 10.0 μM. Anti-osteoporotic activities were investigated using murine osteoclastic RAW 264.7 cells. Compounds 1?7 and 9?12 significantly suppressed tartrate-resistant acid phosphatase activity down to 91.13 ± 1.18 to 42.39 ± 1.11 %, relative to the control (100 %) in nuclear factor-κB ligand (RANκL)-induced osteoclastic RAW 264.7 macrophage cells.
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KEYWORD
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Nepenthes mirabilis, Nepenthaceae, Nepenthoside A, Nepenthoside B, Antioxidant activity, Anti-osteoporosis activity
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